RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
immunofluorescence; RT-PCR etc.
Target
C-SKI
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MiR-34a/miR-93 target c-Ski to modulate the proliferaton of rat cardiac fibroblasts and extracellular matrix deposition in vivo and in vitro
Year
2018
Function
A miR-34a/miR-93-c-SKi axis which modulates TGF-beta1 and isoproterenol (ISO)-induced cardiac fibrosis in vitro and in vivo; Targeting the inhibitory factors of c-SKi to rescue its expression may be a promising strategy for the treatment of cardiac fibrosis.